Asem. A. Moussa

AlazharSchool Of Medicine, Egypt

Abstract

Objective and design: Prospective randomized trial to test the effectiveness of topical oxytocin gel alone Versus High Intensity Focused Ultrasound HIFU in improving Genitourinary Syndrome of menopause GSD in terms of dyspareunia ,Urinary symptoms and dryness in postmenopausal Egyptian women.
Patients and methods: A total of 50 postmenopausal Egyptian women aged52 to 60 years presenting with Genitourinary Syndrome of menopause were enrolled for the study after getting their informed consent and ethical committee approval of the university research were randomized into two groups each of 25 patients; they received intravaginal oxytocin gel of 1 ml for 30 days or HIFU with vaginal tighten cartridge of DS-3mm,DS4.5mm using for each cartridge for one setting in the same setting. Serum estrogen level, visual, colposcopy and histological vaginal examination were performed before and after treatment.

Results:

Fourteen women in the oxytocin gel group improved after treatment and twenty in the HIFU group while Twenty participants in the oxytocin group and twenty one in the HIFU group reported relief of dyspareunia (p = 0.001). There was no significant difference between the circulating levels of estradiol in both groups before and after treatment (p = 0.4 and 0.6 for the Oxytocin group and the HIFU group, respectively).

Conclusion:

Oxytocin gel is useful in the restoration of the vaginal epithelium in cases of postmenopausal atrophic vaginitis however HIFU was more superior and convenient in improving sexual and urinary symptoms in those women. Further studies with a longer follow-up period are required to test the long-term effects of oxytocin and HIFU as a treatment for vaginal atrophy.

Keywords:

Postmenopause, vaginal atrophy, treatment, oxytocin gel ,High Intensity Frequency Ultrasound HIFU

Biography:

Dr.Asem Anwar Moussa is professor of obstetrics and gynaecology at Alazhar School of Medicine and Ex.Directorof theUniversity Maternity Hospital Syed Galal
Consultant of aesthetic and Cosmetic Gynaecology.