Said El Deib¹,  Amr Hawal²

 ¹Royal NMC Hospital Abu Dhabi,
²Amina Hospital, Angelo-Arabian Health Care Group LLC ,

Dubai, UAE

Abstract

Introduction:

Our study aims to state the evidence-based effect of the implementation of newborn infant nutrition with prebiotics&probiotics has been demonstrated  in changing microflora composition toward the desired breast-feeding pattern&stimulating immune respons. Considerable efforts have been made to mimic the composition of human milk by addition to formula feeding of living bacteria (probiotics),non-digestible fibers, nucleotides&oligosaccharides(prebiotics)&bovine lactoferrin in order to induce a breast-fed-similar microbiota colonization in formula-fed infants,with the final aim to stimulate the maturation and proper function of the immune system. Several studies performed in the past decades have clearly demonstrated the complexity of gut microbiota composition and the modulatory effect played by several endogenous and exogenous factors on it.Type of feeding in the first months of life appears as one of the most important determinants of the child and adult well-being,and its protective action seems to rely mainly on its ability to modulate intestinal microflora composition at early stages of life. Diet has a dominant role over other possible variables such ethnicity, sanitation, hygiene, geography, and climate in shaping the gut microbiota.In recent years, the implementation of milk formula with prebiotics, probiotics, and lactoferrin has been demonstrated to change newborns’ microflora composition toward breast-feeding pattern and stimulate immune response Conclusions:The aim of this review is to elucidate the specific immunologic role of the human milk-associated microbiota and its impact on the newborn’s health and life, highlighting the importance to properly study the biological interactions in a bacterial population and between the microbiota and the host.This mini review discusses the composition of human milk and its biological benefit for infants. Additionally, we also discuss how these beneficial effects can be mimicked if breastfeeding is not possible. And to highlight the specific and fundamental role of human milk-associated bacteria in modulating and influencing the newborns’ immune system during their life.      

Biography

Dr. Said El deib is a Pediatrician and Neonatologist whose experience in the field spans 15 years, backed by a higher education degree from royal college in UK. He is pioneering as an open and contextual evaluation model based on constructive responses, which has led in the creation of new methods to improve pediatric healthcare, neonatology and pediatric nutrition. Dr. Said has established this model following his years of experiences in medical practice, research, evaluation, and teaching in hospitals and medical universities in the region, including Egypt, Kuwait and the UAE.